They are economical endotoxin vials for use as standard in endotoxin testing. They replace RSE in an assay and they come with a certificate of analysys.

Control Standard Endotocin (CSE) Product Inserts pdf downloads: CSE 0.5μg/vial | CSE 125μg/vial | CSE 10ng/vial Product Info Sheet

Control Standard Endotoxin (CSE) is a widely used standard for endotoxin testing. It is a purified extract of E. coli O113:H10, the same strain used for the United States Pharmacopeia and the European Pharmacopeia reference standard endotoxin (RSE).

CSE is used as an economic alternative to the RSE. CSEs are standardized against the RSE as indicated on the Certificate of Analysis, so that results can be reported in Endotoxin Units (EU) and International Units (IU). CSE can be used for all LAL testing. A 10 ng/vial CSE is made specifically for use with our Pyrochrome chromogenic reagent.

CSE is used to make standard curves and controls when performing the LAL assay. The concentrations used are dependent on the type of assay (e.g., chromogenic, gel-clot, or turbidimetric) and for photometric methods, the detection range required.

CSE is reconstituted with LRW or equivalent, and is stored at 2-8°C before and after reconstitution. Once reconstituted, the maximum storage time for the different CSE preparations is listed below:
    10 ng/vial - - - - - - - - - - - - - - - - - - - - - - - - - -7 days
    0.5 μg/vial - - - - - - - - - - - - - - - - - - - - - - - - 4 weeks
    125 μg/vial - - - - - - - - - - - - - - - - - - - - - - - 3 months

CSE should not be frozen.

CSE is reconstituted with LAL Reagent Water (LRW) (or equivalent). Please refer to the Certificate of Analysis when using CSE. A Certificate of Analysis exists for each CSE-lysate lot combination.

The most commonly used size is 0.5 μg/vial. The 0.5 μg/vial is also used for testing depyrogenation ovens. The 125 μg/vial is typically used for special purposes, e.g., making endotoxin challenge articles for validation of depyrogenation processes. The 10 ng/vial CSE is available in packs of five vials.